Research

Anti-nausea drug helps HD cells stay healthy in a surprising way

Energy in HD

Energy is a big problem in HD. One of the most common symptoms in
people with HD is weight loss: the emaciated facial features of HD
patients are immediately recognizable to many HD family members.
Surprisingly, not much is known about how and why this happens. HD
patients generally eat as much as people without HD, if not more, but
they have a hard time keeping on weight. So it seems that the problem is not getting enough calories, but some problem with using the energy they consume.

Scientists are beginning to understand that one of the jobs of the
huntingtin protein is to regulate energy production within cells. Dr
Marcy MacDonald's group of researchers have shown that in blood cells from HD patients, longer CAG repeats in the huntingtin gene go along with lower total energy levels. That's important, because longer CAG repeat counts tend to produce an earlier age of onset of the disease.

Because of that link between CAG repeats and energy, researchers have been looking at whether bolstering energy levels might be helpful in HD. Several trials underway, including those with creatine and coenzyme Q10, are based on the idea that increasing energy levels in HD will be helpful.

But symptoms in HD are complex - it can be difficult to figure out
which symptoms are causing the disease, and which symptoms are the body's attempts to deal with it. It's a bit like having a fever - it's
not comfortable, but it's one way the body fights infections. So, are
reduced energy levels in HD causing the disease, or something the body is doing to cope with another problem we don't understand?

Could reducing metabolism be good for HD cells?

A surprise came about two years ago, when a team of researchers
working with Dr Brent Stockwell at Columbia university were looking
for drugs that rescue HD cells from dying. They found that drugs that
slow down metabolism, or energy production, made HD cells healthier.

That caused some confusion - energy levels are low in HD cells, and
many HD patients take drugs aimed at increasing their energy levels.
Despite this, Stockwell's team suggested that or slowing down
metabolism can protect HD cells. Could this be true?

Vamsi Mootha, working with Vishal Gohil and others, has been working to understand the situation. Energy levels are also important in conditions like heart attack and stroke, where important cells are not getting enough oxygen. Previously, Mootha has shown that a compound called meclizine protects heart cells from damage caused by lack of oxygen.

Meclizine works, in part, a bit like the way Stockwell's compounds
worked, so he tested it in another HD cell model. Meclizine does turn
out to protect HD cells from dying, and it does so by slowing down
their metabolism, in agreement with Stockwell's data.

It's not clear if the effects observed by Stockwell and Mootha will
translate from cells to HD patients. In order to improve on simple
cell models, Mootha examined the effects of Meclizine in worm and fly
models of HD. These animal models showed some improvements when treated with Meclizine, but additional studies in mice or rats would be beneficial. Rodent studies take more resources and time to conduct, which is why scientists often study shorter-lived organisms like flies and worms first.

Now what?

This set of unexpected findings demonstrates why we have to be very careful with drug development in HD. On the surface, it's easy to look at a problem like low energy levels and conclude that increasing
energy levels would help. But, if we dig below the surface, the
picture becomes more complex. It's still not clear what aspect of
metabolism is damaging HD cells, or how it's helped by Meclizine, but
you can be sure that these scientists are trying to figure it out.

An interesting twist to the story is that Meclizine is already an
approved drug - but not for HD. It's an anti-nausea drug that's
available over the counter in many countries. It's too early for
anyone to take any drug based on this research, but it's heartening to see that researchers are trying to use drugs in their scientific
studies that could quickly translate to use in humans, once we
understand them better.

Dr. Jeff Carroll

2/3/11
HDBuzz